iron supplementation / colitis
Question:
> Any doctor who just prescribes iron without making sure the > person is already on a complete and balanced supplement regime …just > doesn’t know jack on nutrition.
Just as any salesman who recommends fat-soluble vitamins/supplements to Crohn’s patients who can’t absorb fat doesn’t know jack about IBD.
Response:
For a form of vitamin E that *can" be absorbed by Crohn’s patients, do a Web search on the phrase "water-miscible Vitamin E." There are a number of suppliers out there.
Response:
I really hope this doesn’t come as a surprise to anyone……Nutrients work in synergy! Any doctor who just prescribes iron without making sure the person is already on a complete and balanced supplement regime …just doesn’t know jack on nutrition. Ken.W 7 Years Med Free
– Hide quoted text — Show quoted text -> Another study which recommends supplemention of vitamin E / tocopherol when > one takes iron supplements. > : J Nutr 2002 Oct;132(10):3146-50 Related Articles, Links > Iron supplementation increases disease activity and vitamin e ameliorates the > effect in rats with dextran sulfate sodium-induced colitis. > Carrier J, Aghdassi E, Cullen J, Allard JP. > Department of Medicine, University of Toronto, Toronto, Ontario M5G-2C4, Canada > and. St. Joseph’s Health Centre, Toronto, Ontario, M6R 1B5 Canada. > Inflammatory bowel disease is often associated with iron deficiency anemia and > oral iron supplementation may be required. However, iron may increase oxidative > stress through the Fenton reaction and thus exacerbate the disease. This study > was designed to determine in rats with dextran sulfate sodium (DSS)-induced > colitis whether oral iron supplementation increases intestinal inflammation and > oxidative stress and whether the addition of an antioxidant, vitamin E, would > reduce this detrimental effect. Four groups of rats that consumed 50 g/L DSS in > drinking water were studied for 7 d and were fed: a control, nonpurified diet > (iron, 270 mg, and dl-alpha-tocopherol acetate, 49 mg/kg); diet + iron (iron, > 3000 mg/kg); diet + vitamin E (dl-alpha-tocopherol acetate, 2000 mg/kg) and the > diet + both iron and vitamin E, each at the same concentrations as above. Body > weight change, rectal bleeding, histological scores, plasma and colonic lipid > peroxides (LPO), plasma 8-isoprostane, colonic glutathione peroxidase (GPx) and > plasma vitamin E were measured. Iron supplementation increased disease activity > as demonstrated by higher histological scores and heavier rectal bleeding. This > was associated with an increase in colonic and plasma LPO and plasma > 8-isoprostane as well as a decrease in colonic GPx. Vitamin E supplementation > decreased colonic inflammation and rectal bleeding but did not affect oxidative > stress, suggesting another mechanism for reducing inflammation. In conclusion, > oral iron supplementation resulted in an increase in disease activity in this > model of colitis. This detrimental effect on disease activity was reduced by > vitamin E. Therefore, the addition of vitamin E to oral iron supplementation > may be beneficial. > PMID: 12368409 [PubMed - in process] > Who loves ya. > Tom > Jesus was a vegetarian! http://www.koolpages.com/ironjustice > Jesus was a vegetarian! http://www.nucleus.com/watchman > Moses was a mystic! http://www.nucleus.com/watchman/light.html
Response:
Another study which recommends supplemention of vitamin E / tocopherol when one takes iron supplements. : J Nutr 2002 Oct;132(10):3146-50 Related Articles, Links Iron supplementation increases disease activity and vitamin e ameliorates the effect in rats with dextran sulfate sodium-induced colitis. Carrier J, Aghdassi E, Cullen J, Allard JP. Department of Medicine, University of Toronto, Toronto, Ontario M5G-2C4, Canada and. St. Joseph’s Health Centre, Toronto, Ontario, M6R 1B5 Canada. Inflammatory bowel disease is often associated with iron deficiency anemia and oral iron supplementation may be required. However, iron may increase oxidative stress through the Fenton reaction and thus exacerbate the disease. This study was designed to determine in rats with dextran sulfate sodium (DSS)-induced colitis whether oral iron supplementation increases intestinal inflammation and oxidative stress and whether the addition of an antioxidant, vitamin E, would reduce this detrimental effect. Four groups of rats that consumed 50 g/L DSS in drinking water were studied for 7 d and were fed: a control, nonpurified diet (iron, 270 mg, and dl-alpha-tocopherol acetate, 49 mg/kg); diet + iron (iron, 3000 mg/kg); diet + vitamin E (dl-alpha-tocopherol acetate, 2000 mg/kg) and the diet + both iron and vitamin E, each at the same concentrations as above. Body weight change, rectal bleeding, histological scores, plasma and colonic lipid peroxides (LPO), plasma 8-isoprostane, colonic glutathione peroxidase (GPx) and plasma vitamin E were measured. Iron supplementation increased disease activity as demonstrated by higher histological scores and heavier rectal bleeding. This was associated with an increase in colonic and plasma LPO and plasma 8-isoprostane as well as a decrease in colonic GPx. Vitamin E supplementation decreased colonic inflammation and rectal bleeding but did not affect oxidative stress, suggesting another mechanism for reducing inflammation. In conclusion, oral iron supplementation resulted in an increase in disease activity in this model of colitis. This detrimental effect on disease activity was reduced by vitamin E. Therefore, the addition of vitamin E to oral iron supplementation may be beneficial. PMID: 12368409 [PubMed - in process] Who loves ya. Tom Jesus was a vegetarian! http://www.koolpages.com/ironjustice Jesus was a vegetarian! http://www.nucleus.com/watchman Moses was a mystic! http://www.nucleus.com/watchman/light.html
Response:
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