5-ASA type drugs-a mystery
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Well, they do get absorbed a little, and more if they’re working well for you and your gut’s not so inflamed. Just a guess,mind you. – Hide quoted text — Show quoted text ->Heres whats making me go "Hmmm?". These drugs work locally, right? Active in >the gut & not much absorbtion. So how come when I take these drugs, & only >these drugs, not only does my colon calm down but my gums lose their >inflammation & sores disappear from my tongue? Anyone? >Linda
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If you’re taking any of these, once a year you need to get your kidney function tested (it’s just another blood panel), as one of the few major systemic effects is kidney damage (pancreatitis is the other).
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- Hide quoted text — Show quoted text – > Or maybe some of the ASA is releasing in the mouth, alleviating the > symptoms. > 
mgbio > That is still part of the GI tract.. maybe they are all connected and > the drugs are migrating up through the tissue…. (sounds good > anyway) > Mike > >Heres whats making me go "Hmmm?". These drugs work locally, right? Active in > >the gut & not much absorbtion. So how come when I take these drugs, & only > >these drugs, not only does my colon calm down but my gums lose their > >inflammation & sores disappear from my tongue? Anyone? > >Linda
Hi Linda, 5-ASA is easily absorbed anywhere in the G.I. tract. That’s from lips to lips, so to say. Sulfasalazine, Pentasa, and Asacol have vehicles which deliver the %-ASA to the lower small intestine and beyond. None should be absorbed in the mouth or uper G.I. tract. However, there %-ASA liquids and suspensions which are designed to release in the mouth, esophagaus, and stomach. I’m more inclined to believe that your mouth problems resolved as a result of your bowel inflammation being calmed from the 5-ASA. It’s the abundance of imuno-factors from the major inflammation circulating around which spawn other inflammations. When you calm the major inflammation, that tissue stops calling for more troops, the imuno levels drop back down, and the secondary inflammations will usually go away. Maybe you’ve been taking vitamins or added some nutritious foods to your diet which have helped heal them. Either way I’m glad your doing better. Feel well. William
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>That is still part of the GI tract.. maybe they are all connected and > the drugs are migrating up through the tissue…. (sounds good > anyway)>>
Actually Colozal has been migrating from my stomach to my throat lately. Yuck! Heartburn. Have to take it with lots of water & sit up. Linda
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>I’m more inclined to believe that your mouth problems resolved as a >result of your bowel inflammation being calmed from the 5-ASA. It’s >the abundance of imuno-factors from the major inflammation circulating >around which spawn other inflammations. When you calm the major >inflammation, that tissue stops calling for more troops, the imuno >levels drop back down, and the secondary inflammations will usually go >away.>>
What a good explanation! Sounds very likely to me. >Feel well. > William>>
Thanks William. Same to you. Linda
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>If you look up the action of ASA based drugs .. the latest theory >is they bind up iron.. >In colitis they are using chelators .. and if one does a search of >’gingivitis and iron’ in Medline you will find numerous articles >which speak to iron eating pathogens in the gum ..>>
Very interesting. I guess thats a good side effect of Cipro as well.
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Or maybe some of the ASA is releasing in the mouth, alleviating the symptoms. mgbio – Hide quoted text — Show quoted text -> That is still part of the GI tract.. maybe they are all connected and > the drugs are migrating up through the tissue…. (sounds good > anyway) > Mike >Heres whats making me go "Hmmm?". These drugs work locally, right? Active in >the gut & not much absorbtion. So how come when I take these drugs, & only >these drugs, not only does my colon calm down but my gums lose their >inflammation & sores disappear from my tongue? Anyone? >Linda > Please Visit www.ibdcure.com and sign the petition for an IBD postage stamp. > All opinions expressed are mine unless otherwise noted. > Leah’s Body Sugaring Recipe > Remove unwanted hair > http://www.for-romance.com/sugar > "those that can be offended, will be" … Pastor Don
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Linda, Plenty of drug gets absorbed. Plenty! Accroding to the PDR about 30% of it gets absorbed. That means in all reality it is 40-50% expecially with diseased gut absorbing more. The stuff is pure poison. Thanks, Mike — To reply via email remove the (SPAM_BLOCKER) from my email address:
– Hide quoted text — Show quoted text -> Heres whats making me go "Hmmm?". These drugs work locally, right? Active in > the gut & not much absorbtion. So how come when I take these drugs, & only > these drugs, not only does my colon calm down but my gums lose their > inflammation & sores disappear from my tongue? Anyone? > Linda
Response:
Heres whats making me go "Hmmm?". These drugs work locally, right? Active in the gut & not much absorbtion. So how come when I take these drugs, & only these drugs, not only does my colon calm down but my gums lose their inflammation & sores disappear from my tongue? Anyone? Linda
Response:
That is still part of the GI tract.. maybe they are all connected and the drugs are migrating up through the tissue…. (sounds good anyway) Mike >Heres whats making me go "Hmmm?". These drugs work locally, right? Active in >the gut & not much absorbtion. So how come when I take these drugs, & only >these drugs, not only does my colon calm down but my gums lose their >inflammation & sores disappear from my tongue? Anyone? >Linda
Please Visit www.ibdcure.com and sign the petition for an IBD postage stamp. All opinions expressed are mine unless otherwise noted. Leah’s Body Sugaring Recipe Remove unwanted hair http://www.for-romance.com/sugar "those that can be offended, will be" … Pastor Don
Response:
> Heres whats making me go "Hmmm?". These drugs work locally, right? Active in > the gut & not much absorbtion. So how come when I take these drugs, & only > these drugs, not only does my colon calm down but my gums lose their > inflammation & sores disappear from my tongue? Anyone?
If you look up the action of ASA based drugs .. the latest theory is they bind up iron.. In colitis they are using chelators .. and if one does a search of ‘gingivitis and iron’ in Medline you will find numerous articles which speak to iron eating pathogens in the gum .. Med Hypotheses 1998 Mar;50(3):239-51 A chelate theory for the mechanism of action of aspirin-like drugs. Wang X Department of Pathology, Cornell University Medical College, New York, Two hundred years after the discovery of the pharmaceutical usefulness of aspirin, it and aspirin-like drugs, a family with an ever-increasing number of members, are an indispensable part of modern life. However, the question as to how these drugs work in the body has remained unsettled. It is postulated here that this group of drugs may exert their therapeutic (and adverse) effects by chelating various physiologically important metallic cations in the body. The chelate theory is supported by the vast majority, if not all, of the observations on these drugs made in the past. Publication Types: * Review * Review, academic PMID: 9578329, UI: 98237440 Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc J Periodontal Res 28: 173-9 (1993)[93267368] Characterization of hemolytic bacteria in subgingival plaque. J. D. Hillman, M. F. Maiden, S. P. Pfaller, L. Martin, M. J. Duncan & S. S. Socransky Department of Molecular Genetics, Forsyth Dental Center, Boston, MA. Three-quarters of the patients with periodontal diseases surveyed in this study had one or more distinct types of hemolytic bacteria in their subgingival plaque. Twelve different species of bacteria were identified, belonging to five genera (Actinomyces, Streptococcus, Staphylococcus, Prevotella, and Actinobacillus). Nine hemolytic isolates, consisting of four Prevotella denticola strains, two Actinomyces naeslundii genospecies 2 strains, and one each of P. melaninogenica, Streptococcus constellatus, and A. naeslundii genospecies 1 strains were characterized. Incorporation of pronase into blood agar medium inhibited hemolysis by all of the isolates, suggesting a proteinaceous component for each of their hemolysins. With one exception, hemolysin production appeared to be regulated by the concentration of environmental iron: exogenous hemin was found to inhibit hemolysin production, and the iron scavenging compound, 2,2′- dipyridyl, was found to promote hemolysin production by all of the strains except for the S. constellatus isolate. Genomic libraries of each of the hemolytic plaque isolates were prepared in Escherichia coli using pBR322. Hemolytic clones were isolated on blood agar medium containing ampicillin at frequencies ranging from 1-6.7 x 10(-4). Extensive restriction mapping revealed regions of homology in the case of clones derived from three P. denticola strains isolated from the same subjects. Two of the P. denticola-derived clones were virtually identical throughout the entrety of their > 5 Kb inserts. The clone derived from the third strain showed good homology to the other two within a 1.3 Kb region, but the flanking DNA showed no homology even though all three P. denticola isolates were shown to be clonally related by ribotyping.(ABSTRACT TRUNCATED AT 250 WORDS) MeSH Terms: * Actinobacillus actinomycetemcomitans/isolation & purification * Actinobacillus actinomycetemcomitans/metabolism * Actinobacillus actinomycetemcomitans/pathogenicity * Actinomyces/isolation & purification * Actinomyces/metabolism * Actinomyces/pathogenicity * Bacteroides/isolation & purification * Bacteroides/metabolism * Bacteroides/pathogenicity * Cloning, Molecular * Dental Plaque/microbiology * Genes, Bacterial * Hemolysins/biosynthesis * Hemolysins/genetics * Human * Iron/metabolism * Microbial Sensitivity Tests * Periodontal Diseases/microbiology * Plasmids * Pronase/metabolism * Restriction Mapping * Staphylococcus/isolation & purification * Staphylococcus/metabolism * Staphylococcus/pathogenicity * Streptococcus/isolation & purification * Streptococcus/metabolism * Streptococcus/pathogenicity * Support, U.S. Gov’t, P.H.S. * Virulence Substances: * Iron * Pronase * Plasmids * Hemolysins Who loves ya. Tom — Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
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