Small Bowel Inflammation
Question:
What I was remembering > is that a fair amount (25%) of the med is absorbed in the small > intestine, but despite that it seems it really only works on colitis.
Sulfasalazine can have NON-therapeutic effects above the colon (this is why it often causes nausea and other upper GI disturbances), but the therapeutic effects aren’t available until the sulfapyridine part is broken off from the mesalamine part, and that only happens in the colon, I think. It’s easy to forget that drugs can have all sorts of non-therapeutic effects all over the body, even though we think of them acting only therapeutically (i.e., on only the one part of the body that needs the treatment).
Response:
If your inflammation is restricted to the terminal ileum, pentasa might help. I *think* sulfasalazine works on the small intestine.
Response:
> I *think* sulfasalazine works on the small intestine.
I believe that sulfasalazine doesn’t work until it’s partially broken down by bacteria that are present only in the colon. (Might want to double check.)
Response:
>> I *think* sulfasalazine works on the small intestine. >I believe that sulfasalazine doesn’t work until it’s partially broken >down by bacteria that are present only in the colon. (Might want to >double check.)
I checked, and that seems to be 99% correct. What I was remembering is that a fair amount (25%) of the med is absorbed in the small intestine, but despite that it seems it really only works on colitis. I did see some vague reference to it working on ileocolitis but not on CD’ers with small intestinal illness alone; what was unclear to me was whether those people felt better because at least their colonic inflammation was decreasing, or whether there was some effect in those instances on the terminal ileum as well.
Response:
> >It’s hind sight, but I wonder if remote control, TV ( laproscopic) surgery is >better than hands on, direct vision in many cases. May be "less invasive" but >the "whole picture" is immediately available rather than tunnel vision. > I totally agree! And believe me, I have had many surgeries already, but even > if I were to be offered laproscopic surgery, I would rather have it done the > "old fashioned" way. This way, everything can be seen and nothing is > accidently bumped along the way. Just my 2 cents worth.
The laproscopic surgery I had that bruised my already inflammed small bowel was to perform a tubal ligation – in my opinion, the laproscopy, despite the complications, was the best choice for that procedure.
Response:
It’s hind sight, but I wonder if remote control, TV ( laproscopic) surgery is better than hands on, direct vision in many cases. May be "less invasive" but the "whole picture" is immediately available rather than tunnel vision.
Response:
>What other drugs > are used for small bowel inflammation? Are there any that AREN’T steroids > or NSAIDs? I’m diabetic, so steroid are out
I, too am diabetic, insulin dependant, but I also take Prednisone. Not that I want to, you understand, but because I have to. I just wondered why you could not and what steroids had to do with being diabetic. I know it sounds like a stupid question, but I really don’t know. I have had CD for many years and UC for quite awhile as well. But I am relativly new to diabetes. Please explain. Thanks. Always, Margie CD Class of 67 UC Class of 96
Response:
>It’s hind sight, but I wonder if remote control, TV ( laproscopic) surgery is >better than hands on, direct vision in many cases. May be "less invasive" but >the "whole picture" is immediately available rather than tunnel vision.
I totally agree! And believe me, I have had many surgeries already, but even if I were to be offered laproscopic surgery, I would rather have it done the "old fashioned" way. This way, everything can be seen and nothing is accidently bumped along the way. Just my 2 cents worth. Margie CD Class of 67 UC Class of 96
Response:
> >What other drugs >> are used for small bowel inflammation? Are there any that AREN’T steroids >> or NSAIDs? I’m diabetic, so steroid are out > I, too am diabetic, insulin dependant, but I also take Prednisone. Not that I > want to, you understand, but because I have to. I just wondered why you could > not and what steroids had to do with being diabetic. I know it sounds like a > stupid question, but I really don’t know. I have had CD for many years and UC > for quite awhile as well. But I am relativly new to diabetes. Please
explain. Steroids raise blood gluose levels to unbelievable levels. I am Type II and ‘pill’ dependent; if steroids are used I’d have to go on insulin – not that that would be horrible in itself but I really HATE how steroids make me feel!
Response:
I have small bowel inflammation that is MUCH worse after a recent gynecological laparoscopy. During the surgery, the small bowel was bruised when retracted. It is believed that the cause of this inflammation is Familial Mediterranean Fever, and I am taking colchicine for it. In the meantime, I have a massively distended painful abdomen. What other drugs are used for small bowel inflammation? Are there any that AREN’T steroids or NSAIDs? I’m diabetic, so steroid are out and I have kidney disease, so NSAIDs are out as well. I’m pretty miserable and want to have some suggestions when I see the doc. Also are there any foods to avoid with small bowel inflammation? Anything that’s good to eat?
Response:
I don’t think I can help you with the meds except maybe a pain medication. If you are having a lot of spasms from the colon you can ask about Bentyl and Levbid, which are antispasmatic drugs, Prilocsec to cut down on the acids. As for diet go easy on spicy, fibers, & acidity foods. Diet is a very difficult thing because everyone is different but try to eat stuff that is easy to digest for you. You might ask your doctor about going on a liquid diet or a soft diet to give your gut a time to rest too. Sorry I can’t be of more help. UM MOM Susan
– Hide quoted text — Show quoted text -> I have small bowel inflammation that is MUCH worse after a recent > gynecological laparoscopy. During the surgery, the small bowel was bruised > when retracted. It is believed that the cause of this inflammation is > Familial Mediterranean Fever, and I am taking colchicine for it. In the > meantime, I have a massively distended painful abdomen. What other drugs > are used for small bowel inflammation? Are there any that AREN’T steroids > or NSAIDs? I’m diabetic, so steroid are out and I have kidney disease, so > NSAIDs are out as well. I’m pretty miserable and want to have some > suggestions when I see the doc. > Also are there any foods to avoid with small bowel inflammation? Anything > that’s good to eat?
Response:
I think you want something like turmeric.
– Hide quoted text — Show quoted text -> I have small bowel inflammation that is MUCH worse after a recent > gynecological laparoscopy. During the surgery, the small bowel was bruised > when retracted. It is believed that the cause of this inflammation is > Familial Mediterranean Fever, and I am taking colchicine for it. In the > meantime, I have a massively distended painful abdomen. What other drugs > are used for small bowel inflammation? Are there any that AREN’T steroids > or NSAIDs? I’m diabetic, so steroid are out and I have kidney disease, so > NSAIDs are out as well. I’m pretty miserable and want to have some > suggestions when I see the doc. > Also are there any foods to avoid with small bowel inflammation? Anything > that’s good to eat?
Response:
> I don’t think I can help you with the meds except maybe a pain medication. > If you are having a lot of spasms from the colon you can ask about Bentyl > and Levbid, which are antispasmatic drugs, Prilocsec to cut down on the > acids.
No – this is the SMALL bowel and I have Vicodin for pain. All the excursions up my colon shows no colon problems. – Hide quoted text — Show quoted text -> I have small bowel inflammation that is MUCH worse after a recent > gynecological laparoscopy. During the surgery, the small bowel was bruised > when retracted. It is believed that the cause of this inflammation is > Familial Mediterranean Fever, and I am taking colchicine for it. In the > meantime, I have a massively distended painful abdomen. What other drugs > are used for small bowel inflammation? Are there any that AREN’T steroids > or NSAIDs? I’m diabetic, so steroid are out and I have kidney disease, so > NSAIDs are out as well. I’m pretty miserable and want to have some > suggestions when I see the doc. > Also are there any foods to avoid with small bowel inflammation? Anything > that’s good to eat?
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